These are the worst vault hunters in the Borderlands series, according to lore.

The Borderlands universe is filled with memorable heroes, often equipped with deadly abilities and ruthless personalities. However, this means that on the opposite end of the spectrum, there are some not-so-impressive Vault Hunters out there.
These characters are incredibly unlikely to become Vault Hunting regulars, and it’s a miracle that some of them can even be classed as Vault Hunters in the first place. Despite this, they’re still fantastic additions to the Borderlands universe – they’re just not really meant for Vault Hunting.
Fiona

Out of the core four characters in Tales from The Borderlands, it’s clear that Fiona is the person who can handle herself the best. Fiona has grown up as a con artist and has plenty of sneaky tricks up her sleeve.
Fiona has also had to learn how to survive through various hardships, and after finding her first Vault, she’s seriously ready to go explore some more. Whilst she doesn’t currently have the same experience some of the other Vault Hunters have, it’s likely players will soon see her blossom into a more than capable Vault Hunter in the future.
Fran

Fran has a bit more fighting spirit compared to her counterparts in New Tales from The Borderlands. She isn’t exactly afraid to kill, and quite clearly has some anger issues.
Her hoverchair is equipped with plenty of different gadgets she can use to defend herself, and the player is given multiple opportunities to allow Fran to kill other characters. She’s incredibly confident, but her real passion lies with her frogurt shop – Vault Hunting isn’t exactly at the top of her priority list.
Timothy Lawrence

While in-game, throughout Borderlands: The Pre-Sequel, Timothy (The Doppelganger) is easily one of the most powerful classes in the Borderlands franchise, his character in the lore is slightly less impressive.
Timothy is a bit of a coward and can frequently be heard apologizing to anyone he has to kill. It’s also suggested that he gets his clone to do most of the fighting for him. Timothy simply just doesn’t have the spirit of a Vault Hunter – he only took the job as Jack’s doppelganger to pay off his student debt!
Rhys Strongfork

Players first meet Rhys in Tales from The Borderlands, where he’s a low-ranking Hyperion worker. He quickly finds himself in quite the mess and somehow finds himself becoming a Vault Hunter.
However, it’s quite remarkable how he made it to the Vault in the first place – various scenes throughout the game show that Rhys isn’t built for the Vault Hunter life. He struggles to strange a bandit and is incredibly grossed out by the slightest bit of gore. Poor Rhys is far better suited to his new CEO lifestyle – he probably isn’t looking to take up the Vault Hunter title again any time soon.
Vaughn

At the beginning of Borderlands 3, it’s possible that Vaughn is the worst Vault Hunter of the bunch. However, players soon see him bloom and embrace the life of a bandit on Pandora.
He becomes the leader of his own group and clearly has developed some sort of combat experience and fighting spirit to survive. Although, he’s still not quite there, as players have to rescue him towards the beginning of Borderlands 3. It’s unknown whether Vaughn would be interested in hunting for more Vaults, as he seems quite happy with his newfound bandit life.
Sasha

From the beginning of Tales from The Borderlands, it’s clear that Sasha is more than capable of handling herself – she has experience working with guns but can also defend herself unarmed pretty well.
However, whilst she’s incredibly tough, she only seems to want to fight when she has to. It’s not very likely that she’d purposefully go looking for a fight, and whilst she can handle herself against smaller foes, she might struggle against Vault Monsters.
Octavio

Octavio is incredibly street smart – he’s a wannabe thief and has plenty of gadgets and hacks at his disposal to gather to dirt of anyone he’d like. However, his combat experience and willingness to fight are pretty lacking.
Faring against any of the other Vault Hunters, Octavio would quickly find himself shut down. He was able to outrun a Vault Monster on Promethea, but that was thanks to his sister’s and Fran’s planning. Realistically, Octavio doesn’t stand much of a chance in the Vault Hunting profession and should leave it to the professionals.
Anu

Anu’s character clearly wasn’t meant for Vault Hunting – she’s completely opposed to violence and will collapse into a panic attack at the first sign of things going hectic. Throughout the events of New Tales from The Borderlands, she appears to get by through sheer luck alone.
At one point in the game, she does find herself possessed by the spirit of the shard, however, her body is simply used as a vessel – this isn’t her power or thoughts. It’s unlikely that Anu will find herself searching for Vaults again and probably has no desire to, either.